DuPont has broadened its bioprocessing capabilities with the launch of DuPont AmberChrom TQ1 chromatography resin, supporting the purification of oligonucleotides and peptides for a wide range of biopharmaceutical uses.
“The introduction of DuPont AmberChrom TQ1 chromatography resin supports the accelerated development and commercialization of oligonucleotide and peptide therapeutics,” said Shane Kendra, Global Bioprocessing Market Leader for DuPont Water Solutions. “In addition to expanding our capabilities, this new anion exchange chromatography resin offers exceptional performance, setting a new standard in this product class and creating new opportunities in high growth therapy areas.”
The new agarose-based chromatography resin offers increased loading capacity, higher throughput, and requires less pressure than comparable competing products within the same class. These characteristics make DuPont AmberChrom TQ1 chromatography resin an excellent choice for high resolution separations and polishing, offering high purity fractions in biomolecule purifications and the separation of closely-related impurities from target molecules. Its low-pressure build-up, combined with high-yield and purity for peptides and both DMT-Off and DMT-On oligonucleotides, makes the resin suitable for use in benchtop and large-scale commercial purifications.
To support the introduction of the resin, DuPont has published comprehensive internal application studies that used real-world drug feeds to validate performance characteristics; this documentation can also assist with the integration of the product into processes at every phase from drug discovery through commercialization.
“Further expansion of DuPont’s bioprocessing portfolio reflects our commitment to providing a comprehensive one-stop shop for the purification and polishing of oligonucleotides and peptides,” said Kendra. “Our technical teams and scientists are continually collaborating with customers to design efficient bioprocessing solutions for every stage of the drug development journey.”
DuPont AmberChrom TQ1 chromatography resin can be used in combination with existing AmberChrom XT and CG chromatography resins to purify various oligonucleotide feeds, or for the crude purification of peptide feeds in preparation for reverse phase chromatography.
DuPont introduced the new chromatography resin to the market during TIDES USA—a conference dedicated to accelerating oligonucleotide and peptide innovations. Hadi Fares, Ph.D, a bioprocessing application scientist with DuPont, presented application studies to demonstrate the performance capabilities of DuPont AmberChrom TQ1 chromatography resin, and how it complements existing resins within the DuPont bioprocessing portfolio.
On June 19, 2025, DuPont will host an educational webinar discussing the capabilities of DuPont AmberChrom TQ1 chromatography resin and how its loading capacity and purification efficacy can enhance purification of oligonucleotides and peptides.
As a global market leader in adsorbents and ion exchange resins with over 80 years of experience, DuPont bioprocessing solutions can accelerate and enhance the discovery and production of small molecule synthetics, oligonucleotides, and peptides, as well as diagnostics, by enabling complicated separations that help companies achieve their vision to manage and treat diseases.
